Obesity, hypertension, and the heart

Citation
V. Thakur et al., Obesity, hypertension, and the heart, AM J MED SC, 321(4), 2001, pp. 242-248
Citations number
67
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
ISSN journal
0002-9629 → ACNP
Volume
321
Issue
4
Year of publication
2001
Pages
242 - 248
Database
ISI
SICI code
0002-9629(200104)321:4<242:OHATH>2.0.ZU;2-6
Abstract
Hypertension occurs more commonly in obese than in lean persons at virtuall y every age. A variety of endocrine, genetic, and metabolic mechanisms have been linked to the development of obesity hypertension. These include insu lin resistance and hyperinsulinemia, increased serum aldosterone levels, sa lt sensitivity and expanded plasma volume in the presence of increased peri pheral vascular resistance, a genetic predisposition, and possibly increase d leptin levels. Pressure and volume overload are present in obese hyperten sives. This leads to a mixed eccentric-concentric form of left ventricular hypertrophy and increases the predisposition to congestive heart failure. W eight loss, even in modest decrements, is effective in reducing obesity-hyp ertension, possibly by ameliorating several of the proposed pathophysiologi c mechanisms. There are currently no specific recommendations concerning ph armacotherapy of obesity-hypertension because each drug group has pros and cons.