Experimental laser-assisted in situ keratomileusis induces the reactivation of latent herpes simplex virus

Citation
Dk. Dhaliwal et al., Experimental laser-assisted in situ keratomileusis induces the reactivation of latent herpes simplex virus, AM J OPHTH, 131(4), 2001, pp. 506-507
Citations number
3
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Optalmology,"da verificare
Journal title
AMERICAN JOURNAL OF OPHTHALMOLOGY
ISSN journal
0002-9394 → ACNP
Volume
131
Issue
4
Year of publication
2001
Pages
506 - 507
Database
ISI
SICI code
0002-9394(200104)131:4<506:ELISKI>2.0.ZU;2-W
Abstract
PURPOSE: We determined whether laser-assisted in situ keratomileusis acts a s a trigger for the reactivation and ocular shedding of herpes simplex viru s type-1 in a rabbit latency model. METHODS: Herpes simplex virus type-1 latently infected rabbits were divided into three treatment groups: Group I received surface excimer Laser ablati on in both eyes (positive control), Group II received laser-assisted in sit u keratomileusis in both eyes, and Group III received no treatment (negativ e control). Eyes were cultured daily for 10 days to determine herpes simple x virus type-1 reactivation. RESULTS: The number of herpes simplex virus type-1 positive eye cultures an d total herpes simplex virus type-1 shedding days were significantly greate r after surface excimer laser ablation and laser-assisted in situ keratomil eusis compared with the untreated control group (P < 0.002 and P < 0.000001 , respectively). CONCLUSION: Laser-assisted in situ keratomileusis as well as surface excime r laser ablation act as a trigger for the reactivation of herpes simplex vi rus type-1 in the rabbit latency model. (Am J Ophthalmol 2001;131: 506-507. (C) 2001 by Elsevier Science Inc. All rights reserved).