The immunopathology of actinomycetoma lesions caused by Streptomyces somaliensis

Citation
Am. El Hassan et al., The immunopathology of actinomycetoma lesions caused by Streptomyces somaliensis, T RS TROP M, 95(1), 2001, pp. 89-92
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
0035-9203 → ACNP
Volume
95
Issue
1
Year of publication
2001
Pages
89 - 92
Database
ISI
SICI code
0035-9203(200101/02)95:1<89:TIOALC>2.0.ZU;2-9
Abstract
The immune responses in actinomycetoma lesions caused by Streptomyces somal iensis in Sudan were characterized by immunohistochemistry during 1997-1998 . In sections stained with haematoxylin and eosin, the inflammatory reactio n around the grain was of 2 types. In type I there were 3 zones: a neutroph il zone immediately around the grain, an intermediate zone containing mainl y macrophages, and a peripheral zone consisting of lymphocytes and plasma c ells. Zone 1 stained positively for CD15 (neutrophils), zone 2 for CD68 (ma crophages) and CD3 (T lymphocytes), and zone 3 for CD20 (B lymphocytes). In the type II reaction, there was no neutrophil zone, the grains being surro unded only by macrophages and giant cells. This was confirmed by immunohist ochemistry, which demonstrated the presence of CD3 positive cells. Immunogl obulins G and M and complement were demonstrated on the surface of the grai n and on filaments inside the grain. Neutrophils and macrophages were recru ited into the lesion by complement and were involved in the fragmentation o f the grain. The cytokine profile in the lesion and regional lymph nodes wa s of a dominant Th2 pattern (interleukins-10 and 4).