Cribriform variant papillary thyroid cancer: A characteristic of familial adenomatous polyposis

Citation
Pa. Fenton et al., Cribriform variant papillary thyroid cancer: A characteristic of familial adenomatous polyposis, THYROID, 11(2), 2001, pp. 193-197
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
THYROID
ISSN journal
1050-7256 → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
193 - 197
Database
ISI
SICI code
1050-7256(200102)11:2<193:CVPTCA>2.0.ZU;2-4
Abstract
Inherited cancer syndromes may predispose to more than one type of cancer, and these characteristically develop at an earlier age than their sporadic counterparts. The occurrence in a single individual of multiple, early onse t primary cancers may indicate an inherited cancer susceptibility. Familial adenomatous polyposis (FAP), an autosomal, dominantly inherited susceptibi lity to colorectal adenomas and cancer also predisposes to childhood medull oblastomas and to a specific rare histologic type (cribriform variant) of p apillary thyroid cancer. We describe a patient who developed a childhood me dulloblastoma of the cerebellum, and subsequently a cribriform papillary th yroid cancer. These cancers predated the diagnosis of FAP in this patient, who was later found to have several relatives with FAP. The adenomatous pol yposis coli (APC) mutation delineated in this family was in the region asso ciated with those causing an increased risk of thyroid cancer. We submit th at the diagnosis of the cribriform variant of papillary thyroid cancer in a young individual, especially after a previous cancer diagnosis, should ale rt the physician to the possibility of a diagnosis of FAP.