Effectiveness of ECT combined with risperidone against aggression in schizophrenia

Citation
S. Hirose et al., Effectiveness of ECT combined with risperidone against aggression in schizophrenia, J ECT, 17(1), 2001, pp. 22-26
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
JOURNAL OF ECT
ISSN journal
1095-0680 → ACNP
Volume
17
Issue
1
Year of publication
2001
Pages
22 - 26
Database
ISI
SICI code
1095-0680(200103)17:1<22:EOECWR>2.0.ZU;2-6
Abstract
Aggressive behavior in schizophrenic patients can often be problematic not only for the patients themselves, but for their families and others. This s tudy examined the effect of electroconvulsive therapy (ECT) in combination with risperidone in an open trial in 10 male schizophrenic patients with si gnificant aggressive behaviors. Patients were given bilateral ECT five time s a week in combination with risperidone. The mean total number of times of ECT was 6.6 (range 5-9). The aggressive behavior in five of the six patien ts, who showed positive symptoms, was rapidly ameliorated within 12 days. T he ECT/risperidone regimen also eliminated aggressive behavior in four pati ents showing no positive symptoms within 10 days. These treatment effects l asted for at least 6 months in 9 (of the 10) patients. The results suggest that ECT, combined with risperidone, produce a rapid and effective eliminat ion of aggressive behaviors in schizophrenic patients. In addition, there w as a resolution of aggression in four patients with no positive symptoms. T his suggests that aggression in some schizophrenic patients develops as a p rimary symptom of schizophrenia and is not related to other positive sympto ms of the disease or the patient's personality traits.