Apolipoprotein E polymorphism and response to electroconvulsive therapy

Citation
M. Fisman et al., Apolipoprotein E polymorphism and response to electroconvulsive therapy, J ECT, 17(1), 2001, pp. 11-14
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
JOURNAL OF ECT
ISSN journal
1095-0680 → ACNP
Volume
17
Issue
1
Year of publication
2001
Pages
11 - 14
Database
ISI
SICI code
1095-0680(200103)17:1<11:AEPART>2.0.ZU;2-1
Abstract
The aim of this study was to determine whether the apolipoprotein E genotyp e differs in patients who respond or do not respond to electroconvulsive th erapy (ECT). Inpatients, outpatients, and day-treatment patients who had re ceived ECT comprised the study group. The 34 patients included met DSM-III- R criteria for affective or schizoaffective disorder. Responder or non-resp onder status was assessed using the Clinical Global Inventory and Montgomer y Asberg Depression Rating Scale. Blood samples were taken and coded when t he patients entered the study. DNA extraction and apolipoprotein E genotypi ng were performed with no knowledge of the clinical classification of the p atients. A significant difference in E4 genotype distribution was found bet ween ECT responders and nonresponders (p < 0.02); psychosis was significant ly less frequent in this group (p = 0.046), and there was a trend toward ol der onset of depression among these persons (p = 0.10). Only the E3/3 genot ype was found in the patients with early-onset depression. The E4 genotype appears to define a subgroup of patients with late-onset depression who res pond to ECT. If confirmed in prospective studies, this may provide a useful marker in the treatment decision-making process for late-onset depression.