Computational modeling of RBC and neutrophil transit through the pulmonarycapillaries

Citation
Yq. Huang et al., Computational modeling of RBC and neutrophil transit through the pulmonarycapillaries, J APP PHYSL, 90(2), 2001, pp. 545-564
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
JOURNAL OF APPLIED PHYSIOLOGY
ISSN journal
8750-7587 → ACNP
Volume
90
Issue
2
Year of publication
2001
Pages
545 - 564
Database
ISI
SICI code
8750-7587(200102)90:2<545:CMORAN>2.0.ZU;2-K
Abstract
A computational model of the pulmonary microcirculation is developed and us ed to examine blood flow from arteriole to venule through a realistically c omplex alveolar capillary bed. Distributions of flow, hematocrit, and press ure are presented, showing the existence of preferential pathways through t he system and of large segment-to-segment differences in all parameters, co nfirming and extending previous work. Red blood cell (RBC) and neutrophil t ransit are also analyzed, the latter drawing from previous studies of leuko cyte aspiration into micropipettes. Transit time distributions are in good agreement with in vivo experiments, in particular showing that neutrophils are dramatically slowed relative to the flow of RBCs because of the need to contract and elongate to fit through narrower capillaries. Predicted neutr ophil transit times depend on how the effective capillary diameter is defin ed. Transient blockage by a neutrophil can increase the local pressure drop across a segment by 100-300%, leading to temporal variations in flow and p ressure as seen by videomicroscopy. All of these effects are modulated by c hanges in transpulmonary pressure and arteriolar pressure, although RBCs, n eutrophils, and rigid microspheres all behave differently.