Synthesis and bioactivities of 1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides containing alpha-aminophosphonate groups

Citation
Jm. Huang et Ry. Chen, Synthesis and bioactivities of 1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides containing alpha-aminophosphonate groups, HETEROAT CH, 12(2), 2001, pp. 97-101
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
HETEROATOM CHEMISTRY
ISSN journal
1042-7163 → ACNP
Volume
12
Issue
2
Year of publication
2001
Pages
97 - 101
Database
ISI
SICI code
1042-7163(2001)12:2<97:SABO12>2.0.ZU;2-4
Abstract
In order to search for novel antitumor and antiviral agents with high activ ity and low toxicity, a series of 1-ethoxycarbonylmethyl-3-ethyl-1,2,3,4-te trahydro-4-oxo-1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides containing alpha -aminophosphonate groups have been designed and synthesized by a con venient one-pot procedure in good yields. The structures of products were c onfirmed by H-1 NMR, P-31 NMR, IR spectra, and elemental analyses. The bioa ssay results showed that some of them possess excellent anti-tobacco mosaic virus activities and exhibit higher inhibitory effects compared with that of the contrast drug 2,4- dioxyhexahydro-1,3,5-triazine. (C) 2001 John Wile y & Sons, Inc.