Morphine and clonidine activate different K+ channels on rat amygdala neurons

Citation
R. Murphy et Je. Freedman, Morphine and clonidine activate different K+ channels on rat amygdala neurons, EUR J PHARM, 415(1), 2001, pp. R1-R3
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
0014-2999 → ACNP
Volume
415
Issue
1
Year of publication
2001
Pages
R1 - R3
Database
ISI
SICI code
0014-2999(20010309)415:1<R1:MACADK>2.0.ZU;2-9
Abstract
In cell-attached patch-clamp recordings from freshly dissociated neurons of the rat amygdalohippocampal area, clonidine principally activated a 95-pS (picosiemens) inwardly rectifying K+-permeable channel, whereas morphine ac ting at mu -opioid receptors activated a different 130-pS channel. Clonidin e's effects were largely antagonized by the alpha (2)-adrenoceptor antagoni st idazoxan, but were poorly mimicked by agmatine. These results partially contradict the prevailing hypothesis that alpha (2) and opioid receptors ac t through the same ion channel transduction pathways. (C) 2001 Elsevier Sci ence B.V. All rights reserved.