Hepatic angiomyolipoma: a clinicopathologic study of 10 cases

Citation
Y. Ji et al., Hepatic angiomyolipoma: a clinicopathologic study of 10 cases, CHIN MED J, 114(3), 2001, pp. 280-285
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
CHINESE MEDICAL JOURNAL
ISSN journal
0366-6999 → ACNP
Volume
114
Issue
3
Year of publication
2001
Pages
280 - 285
Database
ISI
SICI code
0366-6999(200103)114:3<280:HAACSO>2.0.ZU;2-R
Abstract
Objective To study the clinicopathologic features of hepatic angiomyolipoma (AML) and to investigate the feasibility of a new antibody-A103 as a diagn ostic aid for AML. Methods Ten cases of AML were retrieved from hospital records and analyzed morphologically. immunohistochemistry was performed on paraffin-embedded ti ssues with a panel of antibodies, including antibody-A103. Results There were eight women and two men, with ages ranging from 38 - 58 years (median 45.7). Clinically, nine cases were asymptomatic and found by imaging techniques. None of the patients had associated tuberous sclerosis. All tumors were sharply demarcated from the surrounding liver parenchyma. Histologically they were composed of a heterogeneous mixture of three compo nents: thick-walled blood vessels, spindle or epithelioid smooth muscle cel ls and adipose tissue. All tumors showed a strong immunoreactivity to A103, HMB-45 and smooth muscle actins. Follow-up information on all 10 cases sho wed a benign course with no signs of recurrence. Conclusions Hepatic AML is a rare mesenchymal tumor of the liver. A103 is a promising marker for a pathologic diagnosis of hepatic AML.