Relationship between bronchial hyperresponsiveness and development of asthma in wheezy infants

Citation
R. Saga et al., Relationship between bronchial hyperresponsiveness and development of asthma in wheezy infants, CHEST, 119(3), 2001, pp. 685-690
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CHEST
ISSN journal
0012-3692 → ACNP
Volume
119
Issue
3
Year of publication
2001
Pages
685 - 690
Database
ISI
SICI code
0012-3692(200103)119:3<685:RBBHAD>2.0.ZU;2-G
Abstract
Study objectives: To evaluate the relationship between bronchial hyperrespo nsiveness (BHR) in infants with wheezing and the subsequent development of asthma. Intervention: Bronchial reactivity to inhaled methacholine (BRm) during the infantile period was studied using the transcutaneous partial pressure of oxygen (tcPo(2)) method. Children were followed long-term for the developme nt of asthma. Patients: Fourteen children with bronchiolitis (mean age, 0.7 years) and 48 with wheezy bronchitis (mean age, 2.3 years) were enrolled. For comparison , 40 children with asthma (mean age, 4.6 years) and 27 healthy control subj ects without chronic respiratory disease (mean age, 2.7 years) were studied . Measurements:: Consecutive doses of methacholine were doubled until a 10% d ecrease in tcPo(2) from baseline Was reached. The cumulative dose of methac holine (Dmin) at the inflection point of tcPo(2) (Dmin-Po-2) was recorded. Results: During > 10 years of follow-up, seven patients with bronchiolitis del eloped asthma and ail patients in the higher BRm set developed asthma, compared with none in the lower BRm set. In the wheezy bronchitis group, Dm in-Po-2 values in the 32 patients who developed asthma were lower than thos e in patients who had not developed asthma (p < 0.001). Conclusions: We concluded that there is a tendency for infants with a clini cal diagnosis of bronchiolitis or wheezy bronchitis and who show BHR in the infantile period to develop asthma. The presence of increased BHR after in fantile respiratory diseases associated with wheezing may be a prelude to t he development of childhood asthma.