Studies on quantum dots-labeled trichosanthin

Citation
Cy. Zhang et al., Studies on quantum dots-labeled trichosanthin, CHEM J CH U, 22(1), 2001, pp. 34-37
Citations number
12
Language
CHINESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
0251-0790 → ACNP
Volume
22
Issue
1
Year of publication
2001
Pages
34 - 37
Database
ISI
SICI code
0251-0790(200101)22:1<34:SOQDT>2.0.ZU;2-U
Abstract
Semiconductor quantum dots were used for the first time to label trichosant hin. The absorption spectrum, fluorescent spectrum and enzymatic activity o f quantum dots-labeled trichosanthin were studied in this paper. The absorb ane of QDs-TCS varied to a-less extent with wavelength in the range of 400- 600 nm. The fluorescent spectrum of QDs-TCS underwent a blue-shift in the e mission peak, but the intrinsic spectral width was unchanged. No changes we re found in the enzymatic activity of QDs-TCS in comparison with trichosant hin. Distribution of QDs-TCS within human choriocarcinoma cells was simulta neously observed with two-photon laser scanning microscopy and confocal las er scanning microscopy. The results indicated that QDs-TCS could enter the cytoplasm across the membrane and aggregated around the nuleolus.