The relationship between plasma concentration of mature adrenomedullin andjugular venous oxygen saturation during and after cardiopulmonary bypass

Citation
S. Fujioka et al., The relationship between plasma concentration of mature adrenomedullin andjugular venous oxygen saturation during and after cardiopulmonary bypass, ANESTH ANAL, 92(4), 2001, pp. 837-841
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ANESTHESIA AND ANALGESIA
ISSN journal
0003-2999 → ACNP
Volume
92
Issue
4
Year of publication
2001
Pages
837 - 841
Database
ISI
SICI code
0003-2999(200104)92:4<837:TRBPCO>2.0.ZU;2-L
Abstract
Adrenomedullin (AM), a vasodilatory peptide, increases during cardiac surge ry. However, the physiological role of AM during cardiac surgery remains un clear. AM dilates cerebral arterioles and increases cerebral blood flow in rats. Therefore, we investigated whether AM is related to cerebral oxygen b alance during cardiac surgery. In nine patients undergoing coronary artery bypass grafts, plasma concentrations of mature AM from the radial artery (m AMa) and jugular bulb (mAMj) were measured, and jugular venous oxygen satur ation was obtained before surgery (baseline), before aortic cross-clamp (pr eclamp), after aortic declamp (postclamp), and 20 min after weaning from th e cardiopulmonary bypass (post-CPB). Plasma concentrations of mAMa and mAMj were significantly increased at postclamp (P < 0.01 for both) and post-CPB (P < 0.01 for both) compared with baseline values. Sjo(2) correlated with plasma mAMj concentrations at preclamp (r = 0.79, P < 0.01), postclamp (r = 0.71, P < 0.05), and post-CPB (r = 0.72, P < 0.05), as well as with mAMa c oncentrations at preclamp (r = 0.79, P < 0.01) and postclamp (r = 0.72, P < 0.05). This suggests a relationship between AM and cerebral oxygen balance during cardiac surgery.