Biological implications of circulating soluble intercellular adhesion molecule-1 in colorectal cancer patients

Citation
T. Araki et al., Biological implications of circulating soluble intercellular adhesion molecule-1 in colorectal cancer patients, SC J GASTR, 36(4), 2001, pp. 399-404
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
0036-5521 → ACNP
Volume
36
Issue
4
Year of publication
2001
Pages
399 - 404
Database
ISI
SICI code
0036-5521(200104)36:4<399:BIOCSI>2.0.ZU;2-V
Abstract
Background: Intercellular adhesion molecule-1 (ICAM-1) is assumed to play a role in cell-cell and cell-extracellular matrix interactions. We evaluated the relationship between local expression of ICAM-1 and the circulating le vel of sICAM-1, and clarified its biological implications. Methods: Serum c oncentrations of sICAM-1 in 94 colorectal cancer patients were determined. Tissue concentrations of sICAM-1 in the tumor, colorectal adenoma, and the normal mucosa were also determined. The expression of ICAM-1 in the tumor w as evaluated immunohistochemically. Results: The serum concentration of sIC AM-1 in the patients was significantly higher than that in the controls, an d the tumor size was the independent pathological factor that was associate d with the serum ICAM-1 level. ICAM-1 immunoreactivity was seen intensively in the stromal cells in the tumor. The tissue concentration of sICAM-1 in the normal mucosa was significantly lower than that in the adenoma and the early carcinoma. The tissue concentration of sICAM-1 in the advanced carcin oma significantly decreased in association with the increase in tumor size. This fluctuation of ICAM-1 expression in the tumor was also associated wit h the metastatic potential even at an early stage of the disease. Conclusio ns: The tissue concentration of sICAM-1 increased during tumorigenesis and at an early stage of carcinoma, and decreased in association with progressi on of the disease. Serum sICAM-1 level reflected the fluctuation of ICAM-1 expression in the tumor. Evaluation of serum concentration of sICAM-1 may b e associated with tumor load and can reflect disease progression in colorec tal cancer patients.