Background: Controversy has existed for many years over whether infant feed
ing methods are related to serum bilirubin concentrations during the first
few days of life. Differences in initial jaundice patterns according to the
feeding method until 72 h after birth have not been elucidated hitherto. T
he difference may become clear in Japanese neonates because jaundice shows
a much higher peak bilirubin concentration and a later peak in Japanese neo
nates than in Caucasian neonates.
Methods: In the present study, we investigated variations in the transcutan
eous bilirubin reading (TcB) obtained within 72 h after birth among 177 bre
ast-fed and 494 formula-fed healthy Japanese term neonates.
Results: There was no difference between TcB in formula-fed and breast-fed
infants until the first 30 h, after which time the rate of increase in TcB
was lower in formula-fed infants. Among breast-fed neonates, a good linear
regression between time after birth and TcB was maintained. Similarly, weig
ht losses in breast-fed infants at 24-48 h and 48-72 h after birth were gre
ater than those in formula-fed infants.
Conclusions: The jaundice pattern in Japanese neonates from 30 to 72 h afte
r birth according to the feeding method was different from that in Caucasia