Characterization of hyperplastic foci observed in surgical specimens of hepatocellular carcinoma

Citation
K. Kato et al., Characterization of hyperplastic foci observed in surgical specimens of hepatocellular carcinoma, PATHOL INT, 51(1), 2001, pp. 20-25
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGY INTERNATIONAL
ISSN journal
1320-5463 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
20 - 25
Database
ISI
SICI code
1320-5463(200101)51:1<20:COHFOI>2.0.ZU;2-T
Abstract
By reviewing previous surgical specimens of hepatocellular carcinoma, 17 ca ses with hyperplastic foci (HPF) characterized by discernible increase in n uclear densities, could be histologically selected. Nuclear densities of HP F and control hepatic parenchyma were assessed quantitatively by counting t he nuclear number of hepatic cells, and proliferating cell nuclear antigen labeling index was measured. HPF occurred multifocally, confined within a l obular unit, smoothly merging into surrounding hepatic parenchyma. Nuclear densities of HPF were 1.71 times greater than those of control hepatic pare nchyma. The hepatocytes of HPF also showed significantly higher proliferati ve activities than those of control parenchyma. In addition, noticeable str uctural distortions, such as focal trabecular thickening or microacinar for mation of hepatocytes, were sometimes observed in HPF. However, these HPF s eemed to be distinguished from minute de novo hepatocellular carcinoma (HCC ) or intrahepatic HCC metastasis, because of paucity of distinctive atypica l changes, and intimate correlation with neighboring hepatocytes. Several a djacent HPF were aggregated to form a much larger unit of a hyperplastic ar ea with loss of fibrous septa of liver cirrhosis. It was suggested that gro ssly detectable large regenerative nodules are produced via fusion of sever al adjacent HPF.