Clinicopathological study of a hilar nodule in the livers of long-term survivors with biliary atresia

Citation
R. Ijiri et al., Clinicopathological study of a hilar nodule in the livers of long-term survivors with biliary atresia, PATHOL INT, 51(1), 2001, pp. 16-19
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGY INTERNATIONAL
ISSN journal
1320-5463 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
16 - 19
Database
ISI
SICI code
1320-5463(200101)51:1<16:CSOAHN>2.0.ZU;2-E
Abstract
With the application of liver transplantation for patients with biliary atr esia (BA), we have had the opportunity to review the clinicopathologic feat ures of the native livers from 10 transplanted BA patients. A single large nodule at porta hepatis (hilar nodule) was noted in three of 10 patients, a nd an ill-defined nodule-like lesion at porta hepatis was present in two ot her patients. The three BA patients with hilar nodules were long-term survi vors, compared to the patients with nodule-like and those without nodules. The hilar nodules measured between 5.0 cm and 8.0 cm and histologically, th ey were partly surrounded by fibrous septa with relatively well-preserved l iver architectures and fewer inflammatory cells at the portal triads when c ompared to the surrounding cirrhotic lesions. No nuclear or cellular atypia was observed. Proliferating cell nuclear antigen labeling index was higher in the surrounding cirrhotic lesions than the hilar nodules. The nodule-li ke lesions at porta hepatis also showed similar light microscopic and immun ohistochemical features as the hilar nodules. These hilar nodules did not s eem to contain any malignant potential. The benign histology with relativel y well-preserved liver architecture and the preferential site of occurrence at porta hepatis where bile seemed to flow more smoothly, suggested possib le residues of less-affected hepatic tissues.