An example of an improvement in recovering ammonia in a dipeptide manufactu
ring process is described. The synthetic method, which makes use of the amm
onolysis reaction, has been studied and found to produce dipeptides of sati
sfactory quality in high yield on a large scale. However, the treatment of
unreacted ammonia in the ammonolysis reaction caused a reduction in the pro
ductivity and increased the production cost during actual manufacture, Ther
efore, a method to recover the unreacted ammonia has been investigated thro
ugh simulations and trial runs using model solutions, Consequently, the mod
ified process provided an improvement in the productivity and cost savings.
In addition, the recovered ammonia could possibly be used for recycling. I
t was verified in a lab experiment that the reused ammonia did not lower th
e quality of the dipeptide.