Recovery of ammonia in the dipeptide manufacturing processes

Citation
S. Kato et al., Recovery of ammonia in the dipeptide manufacturing processes, ORG PROC R, 5(2), 2001, pp. 132-135
Citations number
2
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
1083-6160 → ACNP
Volume
5
Issue
2
Year of publication
2001
Pages
132 - 135
Database
ISI
SICI code
1083-6160(200103/04)5:2<132:ROAITD>2.0.ZU;2-4
Abstract
An example of an improvement in recovering ammonia in a dipeptide manufactu ring process is described. The synthetic method, which makes use of the amm onolysis reaction, has been studied and found to produce dipeptides of sati sfactory quality in high yield on a large scale. However, the treatment of unreacted ammonia in the ammonolysis reaction caused a reduction in the pro ductivity and increased the production cost during actual manufacture, Ther efore, a method to recover the unreacted ammonia has been investigated thro ugh simulations and trial runs using model solutions, Consequently, the mod ified process provided an improvement in the productivity and cost savings. In addition, the recovered ammonia could possibly be used for recycling. I t was verified in a lab experiment that the reused ammonia did not lower th e quality of the dipeptide.