Comparison of the expression of ABH/Lewis-related antigens in polypoid andnon-polypoid growth types of colorectal carcinoma

Citation
T. Nakagoe et al., Comparison of the expression of ABH/Lewis-related antigens in polypoid andnon-polypoid growth types of colorectal carcinoma, J GASTR HEP, 16(2), 2001, pp. 176-183
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
ISSN journal
0815-9319 → ACNP
Volume
16
Issue
2
Year of publication
2001
Pages
176 - 183
Database
ISI
SICI code
0815-9319(200102)16:2<176:COTEOA>2.0.ZU;2-K
Abstract
Background and Aims: Colorectal tumors can be classified based on their gro wth pattern into the polypoid growth-type (PG-type) and non-polypoid growth -type (NPG-type). To ascertain whether there is any relationship between th e expression of particular blood group-related antigens (A, B, H, Lewis (Le ) (a), sialyl Le(a), Le(x), sialyl Le(x)) in a colorectal tumor, and a tumo r having polypoid or non-polypoid growth, we examined 78 PG-type and NPG-ty pe colorectal cancers. Methods: Fourteen PG-type and 64 NPG-type colorectal carcinomas were subjec ted to immunohistochemical analyses by using monoclonal antibodies against A, B, H, Le(a), sialyl Le(a), Le(x) and sialyl Le(x). Results: The patients with NPG-type carcinomas had a significantly younger age of onset, significantly smaller maximal tumor diameter, significantly h igher rate of lymph node metastasis and significantly worse prognosis than those with PG-type carcinomas. Among the 32 tumors of patients with blood t ype A or AB, isoantigen A was expressed in a significantly larger percentag e of NPG-type carcinomas than PG-type carcinomas (95.8 vs 62.5%, respective ly; P = 0.014). Among all 78 tumors, sialyl Le(x) antigen was expressed in a significantly larger percentage of NPG-type than PG-type carcinomas (90.6 vs 64.3%, respectively; P = 0.010). Multivariate analysis using the logist ic regression model revealed that isoantigen A and sialyl Le(x) expression were independent predictive risk factors for the development of NPG-type co lorectal carcinoma. Conclusions: These data suggest that the expression of isoantigen A and sia lyl Le(x) in a colorectal carcinoma partially determines whether the tumor will have polypoid or non-polypoid growth. (C) 2001 Blackwell Science Asia Pty Ltd.