Atrial fibrillation impairs endothelial function of forearm vessels in humans

Citation
N. Takahashi et al., Atrial fibrillation impairs endothelial function of forearm vessels in humans, J CARD FAIL, 7(1), 2001, pp. 45-54
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF CARDIAC FAILURE
ISSN journal
1071-9164 → ACNP
Volume
7
Issue
1
Year of publication
2001
Pages
45 - 54
Database
ISI
SICI code
1071-9164(200103)7:1<45:AFIEFO>2.0.ZU;2-2
Abstract
Background: Although there have been many studies on the effects of atrial fibrillation (AF) on cardiac function. few studies have been done on its ef fects on endothelial function. The present study was designed to examine th e effects of AF on endothelial function in human Subjects. Methods and Results: Changes in forearm blood flow (FBF) induced by acetylc holine and nitroglycerin were measured by using plethysmography in 14 patie nts with lone AF. 13 patients with AF and underlying heart disease, and 12 normal control subjects. In the patients. these measurements were repeated after cardioversion. Although baseline FBF was the same in the 3 groups, ac etylcholine-induced increases in FBF were significantly smaller in both pat ient groups than in the control group, and FBF increases were particularly depressed in AF patients with underlying heart disease. After restoration o f sinus rhythm by cardioversion, FBF response to the highest dose of acetyl choline increased by 46% in patients with lone AF (n = 10) and by 90% in AF patients with underlying heart disease (n = Il). Nitroelycerin-induced vas odilatation was the same in all 3 groups and was not affected by cardiovers ion. Conclusions: These findings suggest that endothelium-dependent vasodilatati on is impaired by AF and improves after sinus rhythm is restored.