Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy

Citation
M. Shimizu et al., Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy, JPN CIRC J, 65(4), 2001, pp. 325-329
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
ISSN journal
0047-1828 → ACNP
Volume
65
Issue
4
Year of publication
2001
Pages
325 - 329
Database
ISI
SICI code
0047-1828(200104)65:4<325:SDABPR>2.0.ZU;2-0
Abstract
Left ventricular function and blood pressure responses were evaluated in 56 patients with non-obstructive hypertrophic cardiomyopathy (HCM) and 12 con trol subjects by using a radionuclide ventricular function monitor during s upine ergometer exercise. Patients with HCM were divided into 2 groups: (i) group A had no decrease in ejection fraction (EF) during exercise; and (ii ) group B had a decrease in EF during exercise. During exercise, the change in end-diastolic volume did not differ between the 3 groups. In contrast, the change in end-systolic volume differed between the 3 groups (p<0.0001), The change in systolic blood pressure (SBP) also differed significantly be tween the 3 groups. The change in SEP in group B was smaller than that in t he control group and group A, and changes in the EF and changes in the SEP between rest and peak exercise showed a significant correlation (p<0.005), These results suggest that exercise induced systolic dysfunction in patient s with non-obstructive HCM may contribute to abnormal blood pressure respon se in those patients.