Coronary lesion morphology and prognosis in young males with myocardial infarction with or without familial hypercholesterolemia

Citation
T. Yasuda et al., Coronary lesion morphology and prognosis in young males with myocardial infarction with or without familial hypercholesterolemia, JPN CIRC J, 65(4), 2001, pp. 247-250
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
ISSN journal
0047-1828 → ACNP
Volume
65
Issue
4
Year of publication
2001
Pages
247 - 250
Database
ISI
SICI code
0047-1828(200104)65:4<247:CLMAPI>2.0.ZU;2-3
Abstract
The present study examined the angiographic characteristics and prognosis o f young males under 30 years of age with acute myocardial infarction (AMI) and familial hypercholesterolemia (FH). The study group was divided into an FH group (n=16) and a non-FH group (n=27). Lesion morphology was classifie d as complex or smooth. Overall 36 patients were followed up for an average of 9.3 years. The frequency of angiographic normal or nonobstructive culpr it lesions was significantly higher in the non-FH group (p<0.01). In contra st, the incidence of complex or totally occlusive lesions was higher in the FH group (p<0.01). At 10-year follow-up, survival rates from cardiac death (FH 85% vs non-FH 100%, p=0.06), from AMI (FH 43% vs non-FH 80%, p<0.05), and from any ischemic event at a new lesion (FH9% vs non-FH 67%, p<0.01) we re all reduced in the FH group. These results suggest that the mechanism of AMI in young male patients with FH differs from that in similar aged patie nts without FH, and that the overall prognosis of these patients is less fa vorable.