Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?

Citation
S. Wada et al., Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?, INT J UROL, 8(3), 2001, pp. 106-109
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
INTERNATIONAL JOURNAL OF UROLOGY
ISSN journal
0919-8172 → ACNP
Volume
8
Issue
3
Year of publication
2001
Pages
106 - 109
Database
ISI
SICI code
0919-8172(200103)8:3<106:ATUAUP>2.0.ZU;2-S
Abstract
Background: Many case-control and cohort studies have shown a positive rela tionship between bladder carcinoma and tobacco use. Recently, urine pH has been reported to influence aromatic amine carcinogenesis, which have been i mplicated as potent carcinogens in bladder carcinoma patients. Herein the c orrelation between bladder carcinoma, tobacco use and urine pH is reported. Method: One hundred and forty-one patients with bladder carcinoma and 128 p atients with benign prostatic hyperplasia or urolithiasis as controls were selected. All patients were admitted to Osaka City University Hospital for the purpose of surgical treatment. Urine pH was checked by a test tape. Results: Of the patients with bladder carcinoma, 106 were smokers and 35 we re non-smokers. In contrast, the number of smokers in the control group was 76 and that of non-smokers was 52. The odds ratio in the bladder carcinoma group calculated for the smoker patients was 2.07, showing a significant c orrelation between bladder carcinoma and tobacco use. Regarding urine pH, a cidic urine was found in 126 patients in the bladder carcinoma group and in 116 patients in the control group. The odds ratio in the bladder carcinoma group for acidic urine was 0.87, showing no significant relationship betwe en bladder carcinoma and urine pH. Conclusion: The study found a positive relationship between bladder carcino ma and tobacco use; however, it could not establish a clear relationship be tween bladder carcinoma and urine pH, even in the smoker group.