Background: Many case-control and cohort studies have shown a positive rela
tionship between bladder carcinoma and tobacco use. Recently, urine pH has
been reported to influence aromatic amine carcinogenesis, which have been i
mplicated as potent carcinogens in bladder carcinoma patients. Herein the c
orrelation between bladder carcinoma, tobacco use and urine pH is reported.
Method: One hundred and forty-one patients with bladder carcinoma and 128 p
atients with benign prostatic hyperplasia or urolithiasis as controls were
selected. All patients were admitted to Osaka City University Hospital for
the purpose of surgical treatment. Urine pH was checked by a test tape.
Results: Of the patients with bladder carcinoma, 106 were smokers and 35 we
re non-smokers. In contrast, the number of smokers in the control group was
76 and that of non-smokers was 52. The odds ratio in the bladder carcinoma
group calculated for the smoker patients was 2.07, showing a significant c
orrelation between bladder carcinoma and tobacco use. Regarding urine pH, a
cidic urine was found in 126 patients in the bladder carcinoma group and in
116 patients in the control group. The odds ratio in the bladder carcinoma
group for acidic urine was 0.87, showing no significant relationship betwe
en bladder carcinoma and urine pH.
Conclusion: The study found a positive relationship between bladder carcino
ma and tobacco use; however, it could not establish a clear relationship be
tween bladder carcinoma and urine pH, even in the smoker group.