Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm

Citation
Y. Kishimoto et al., Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm, EUR J NEURO, 13(6), 2001, pp. 1249-1253
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
EUROPEAN JOURNAL OF NEUROSCIENCE
ISSN journal
0953-816X → ACNP
Volume
13
Issue
6
Year of publication
2001
Pages
1249 - 1253
Database
ISI
SICI code
0953-816X(200103)13:6<1249:CECIGR>2.0.ZU;2-9
Abstract
In mice lacking glutamate receptor subunit delta2 (GluR delta2(-/-) mice), cerebellar long-term depression (LTD) at the parallel fibre-Purkinje cell s ynapses is disrupted. Unlike the cerebellar LTD-deficient mice previously u sed for eyeblink conditioning, however, the abnormalities of the GluR delta 2(-/-) mice are restricted to the cerebellar cortex. In delay eyeblink cond itionings (interstimulus interval of 252 and 852 ms), in which the conditio ned stimulus (CS) overlaps temporally with a coterminating unconditioned st imulus (US), GluR delta2(-/-) mice are severely impaired in learning, stron gly supporting the hypothesis that cerebellar cortical LTD is essential for delay conditioning. In the trace paradigm, in which a stimulus-free trace interval of 500 ms intervened between the CS and US, GluR delta2(-/-) mice learned as successfully as wild-type mice, indicating that cerebellar LTD i s not necessary for trace conditioning. Thus, the present study has reveale d a cerebellar LTD-independent learning in eyeblink conditioning.