Quantitative assessment of diffuse coronary artery disease using a three-dimensional reconstruction method compared with intravascular ultrasound images

Citation
T. Tsuchiya et al., Quantitative assessment of diffuse coronary artery disease using a three-dimensional reconstruction method compared with intravascular ultrasound images, CORON ART D, 12(2), 2001, pp. 127-133
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
CORONARY ARTERY DISEASE
ISSN journal
0954-6928 → ACNP
Volume
12
Issue
2
Year of publication
2001
Pages
127 - 133
Database
ISI
SICI code
0954-6928(200103)12:2<127:QAODCA>2.0.ZU;2-6
Abstract
Background It can be difficult to estimate the degree of stenosis in patien ts with diffuse coronary artery disease (CAD), because of the lack of a nor mal reference segment. If the size of normal coronary lumen has a direct re lation to size of distal myocardial bed, it could be used to estimate the ' normal' cross-sectional area of coronary lumen. Accordingly, we could estim ate the degree of stenosis of coronary arteries with diffuse disease by com paring them with calculated 'normal' areas of lumen. Objective To assess the validity of the above hypothesis. Method Fourteen subjects without coronary atherosclerosis (group A) and 16 patients with CAD (group B) underwent simultaneous bidirectional coronary a rteriography. Using these coronary arteriograms, we determined the relation ship between cross-sectional area of coronary lumen measured by using a com puterized edge-detection system and summed distal branch length calculated by using our computerized three-dimensional reconstruction method. Results For group A, we found a dose correlation between area of lumen and branch length (r = 0.948). However, for group B, there were some segments f or which the measured area of lumen was clearly smaller than that expected from the relationship for group A. From this relationship for group A, we c alculated the stenosis ratios of 22 segments and, to confirm their accuracy , we compared the stenotic ratios with those measured on intravascular ultr asound images. The stenotic ratio of each segment of stenotic coronary arte ry calculated by our method agreed significantly well with the results obta ined from the ultrasound measurements (r = 0.980). Conclusions These observations validate a novel approach to quantifying dif fuse CAD using clinical arteriograms. Coron Artery Dis 12:127-133 (C) 2001 Lippincott Williams & Wilkins.