Procalcitonin does not discriminate infection from inflammation after allogeneic bone marrow transplantation

Citation
Nma. Blijlevens et al., Procalcitonin does not discriminate infection from inflammation after allogeneic bone marrow transplantation, CL DIAG LAB, 7(6), 2000, pp. 889-892
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071-412X → ACNP
Volume
7
Issue
6
Year of publication
2000
Pages
889 - 892
Database
ISI
SICI code
1071-412X(200011)7:6<889:PDNDIF>2.0.ZU;2-E
Abstract
Procalcitonin (PCT) is an early marker of bacterial infection but little is known about its value in neutropenic allogeneic bone marrow transplant (BM T) recipients. We collected plasma from 12 recipients of T-cell-depleted HL A-matched related BMT recipients who had been treated preemptively with mer openem from the day after BMT for at least 15 days. PCT and C-reactive prot ein (CRP) concentrations were determined on BMT days 1, 5, 8, 12, and 15, a nd their relationship to inflammatory events (IE), including mucositis, mic robiologically and clinically defined infections, acute graft-versus-host d isease (GVDH), and unexplained fever, was then determined. The PCT concentr ations were all low and never exceeded 1 mug/liter, unlike CRP concentratio ns, which spanned the full range up to 350 mg/liter. All patients had mucos itis, and there was no significant difference between PCT concentrations as sociated with mucositis alone and those associated with an additional IE on BMT days I to 12, However, on BMT day 15, the mean concentrations of PCT w ere 0.37 +/- 0.05 mug/liter for the 10 patients that had an additional IE, compared with 0.11 +/- 0.03 mug/liter for the 2 patients with mucositis onl y (P = 0.012), and GVHD rather than infection was involved in six cases. PC T was also not a sensitive marker of gram-positive bacteremia or pulmonary aspergillosis. Thus, PCT is of little value in discriminating infections fr om other inflammatory complications that occur following allogeneic BMT.