Molecular genetic analysis of the calcineurin signaling pathways

Citation
R. Sugiura et al., Molecular genetic analysis of the calcineurin signaling pathways, CELL MOL L, 58(2), 2001, pp. 278-288
Citations number
75
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
2
Year of publication
2001
Pages
278 - 288
Database
ISI
SICI code
1420-682X(200102)58:2<278:MGAOTC>2.0.ZU;2-Y
Abstract
Calcineurin is a Ca2+ and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the p owerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T ce ll activation, muscle hypertrophy, memory development, glucan synthesis, io n homeostasis, and cell cycle control. Notably, specific transcription fact ors have been shown to play a key role in regulating these functions, and t heir calcineurin-mediated dephosphorylation and nuclear translocation appea r to be a central event in the signal transduction pathways. This review fo cuses on recent process in these areas and discusses the evidence for cross -talk between calcineurin and other signaling pathways.