PREAMI: Perindopril and remodelling in elderly with acute myocardial infarction: Study rationale and design

Authors
Battaglia, A Ferraro, L Lo Monaco, M Palumbo, A Mariani, M Biadi, O Boccalatte, A Polimeno, S De Rosa, V Liguori, L Cuomo, S Boccanelli, A Morosetti, P D'Angelo, G Bottiglieri, P Brunelli, C Spallarossa, P Rolandi, A Rossettini, PF Campa, P Barilla, F De Biase, L Biscosi, C Zampino, D Capponi, E Buccolieri, M Gattobigio, R Capucci, A Passerini, F Piepoli, M Castello, A Chiariello, M Betocchi, S Ciampi, Q Losi, M Corsini, G Melorio, S Dalle Mule, J Mazzella, M Cristinziani, GR Mario, L De Luca, I Fusco, F Del Salvatore, B Sorino, M Delise, P Mozzato, MG Bilardo, G Coro', L Fantinel, M Zasso, A Fedele, F Di Donato, D Romano, S De Pascale, F Giasi, M Ciarcia, L Lizzardo, A Mastursi, M Giordano, A Benigno, M Zanelli, E Campana, M Giovannini, E Lacche, A Pulignano, G Giuffrida, G Montana, G Licciardello, G L'Abbate, A Carpeggiani, C Morales, A Leghissa, R Mandorla, S Del Pinto, M Borgioni, C Mininni, N Petrillo, ME Moretti, G Bonaglia, M Zoni, A Piscicelli, C Orlandi, M Panciroli, C Oddone, A Caizzi, V Tartarini, G Lattanzi, F Reisenhofer, B Pascotto, P Zanocco, A Dabizzi, RP Bini, L Mondanelli, D Frascarelli, F Pitscheider, W Erlicher, A Rauhe, W Bonsante, E Polimeni, M Catananti, F Guerrisi, G Magnani, B Rapezzi, C Ferlito, M Amati, S Di Leo, L Manzo, M Baldi, C De Cristofaro, M Citro, R Raviele, A Turiano, G Zuin, G Rengo, F Furgi, G Papa, A Rotiroti, D Rosato, G Siano, F Pagliuca, MR Rovelli, G Heyman, J Locati, I Sanguinetti, M Tomassini, F Mantovani, R Sanna, A Marras, L Crabu, E Locci, G Moio, N Scilla, C Tavazzi, L Magrini, G Bersano, C Laudisa, ML Trimarco, B Argenziano, L Silvestri, S Valagussa, F Ciro, E Cantu, E Trocino, G Rossillo, A Valagussa, L Finocchi, G Benvenuto, GM Bonanno, C Ometto, R Risica, G Gualandi, G Facchin, L Tenderini, P Nicolosi, GL Burelli, C Macor, F Bellone, E Laiso, D Carvalho, P Peila, C Fagiano, A Gardiol, S Ganci, B Presutto, P Fontanelli, A Morgera, T Scarpino, L Barbuzzi, S Capogrosso, V Terrosu, PF Contini, GM Sabino, G Pes, R Uneddu, F Mecca, D De Tommaso, I Rusconi, C Brunazzi, MC Codeluppi, P Pasqualini, M Gorni, R Negrelli, M Paparoni, S Core, A Pecce, P Petrella, L Zennaro, RG Garuti, W Alfano, G Bacca, F Petrucci, G Paci, AM Bigalli, G Mangiameli, S Gulizia, M Cardillo, R Ferrari, G Tettamanti, F Butti, E Picchione, N Sulla, A Stroder, P Perna, GP Ricci, S Generali, CA Adornato, E Ghisio, A Tidu, M Ferrari, R Mele, D Cicchitelli, G Merli, E Russa, O Azcarate, JMA Gonzales, PZ Vilchez, F Alonso, LFI Montero, JMM Zarzosa, CD Martin, ES de Ros, JO Martinez, MH Palau, VM de Carranza, MST Mayor, DJLB Cocina, EG Valderrama, JC Jimenez, RP Pardo, JAM Cortada, JB Lorente, LJ Guerrero, JJG Martinez, A Coronado, JLB Casado, RS Cendon, AA Cokkinos, D Maounis, T Karatasakis, G Kremastinos, D Iliodromitis, S Karatzas, D Georgiadis, M Paraskevaidis, I Toutouzas, P Antoniadis, P Angeli, C Vadas, P Kaleboubas, M Stamatelopoulos, S Nanas, I Kanakakis, A Dalianis, A Zacharoulis, A Fotiadis, I Pyrgakis, V Liata, O Mazen, B Kardaras, F Kardara, D Krokos, V Sioras, H Fousas, S Stefanidis, A Papadopoulos, G Papadopoulos, C Papagiannis, I Karidas, I Zobolos, S
Citation
A. Battaglia et al., PREAMI: Perindopril and remodelling in elderly with acute myocardial infarction: Study rationale and design, CARDIO DRUG, 14(6), 2000, pp. 671-679
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CARDIOVASCULAR DRUGS AND THERAPY
ISSN journal
0920-3206 → ACNP
Volume
14
Issue
6
Year of publication
2000
Pages
671 - 679
Database
ISI
SICI code
0920-3206(200012)14:6<671:PPARIE>2.0.ZU;2-E
Abstract
Angiotensin-converting enzyme (ACE) inhibitors reduce mortality, the develo pment of remodeling, left Ventricular (LV) dysfunction, and ischemic events , both when administered alone as long-term treatment in patients with impa ired LV function and/or heart failure (HF) and as short-term treatment, ear ly after acute myocardial infarction (AMI) and/or HF. The few data availabl e on the use of ACE inhibitors in the elderly after AMI are conflicting. No ticing is known about the effects of ACE inhibitors in elderly postinfarcti on patients with preserved LV function: these patients have a remarkable me dium- to long-term mortality and HF incidence after infarction. The aim of this study is to evaluate, in patients with AMI aged greater than or equal to 65 years, the effects of Perindopril on the combined outcome of death, h ospitalization for HF, and heart remodeling, considered to be a greater tha n or equal to8% increase in LV end-diastolic volume (LVEDV). Secondary obje ctives include the same factors listed in the primary end points but consid ered separately. In addition, safety of the drug, ventricular remodeling, a nd adaptation are being evaluated. A total of 1100 patients with AMI (first episode or reinfarction), aged greater than or equal to 65 years, and pres erved or only moderately depressed LV (LV ejection fraction greater than or equal to 40%), are to be enrolled and randomly assigned to treatment (8 mg for 12 months of Perindopril or placebo, in double-blind conditions). Clin ical assessment is performed at fixed times, and periodic evaluations of (1 ) ventricular shape, dimensions, and function by quantitative 2-D echocardi ography, and (2) heart rate variability and arrhythmias by ambulatory elect rocardiographic monitoring are anticipated. The results and conclusions wil l be available by 2002 year.