Introduction of tissue engineering concepts into the field of endovasculargrafts: An attempt to solve endoleakage problems of endovascular grafts implanted in aortic aneurysms

Citation
Y. Noishiki et al., Introduction of tissue engineering concepts into the field of endovasculargrafts: An attempt to solve endoleakage problems of endovascular grafts implanted in aortic aneurysms, ARTIF ORGAN, 25(3), 2001, pp. 228-235
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
ARTIFICIAL ORGANS
ISSN journal
0160-564X → ACNP
Volume
25
Issue
3
Year of publication
2001
Pages
228 - 235
Database
ISI
SICI code
0160-564X(200103)25:3<228:IOTECI>2.0.ZU;2-F
Abstract
To solve endoleakage problems of endovascular prostheses inserted in aortic aneurysms, a concept originating from tissue engineering was proposed. We proposed that in order to accelerate the thrombus inside the aneurysm, thre e major factors for successful tissue engineering, i.e., appropriate cells, extracellular matrices, and growth factors, should be introduced into a sp ace between the endovascular grafts and the aneurysm. As a simulation model in animals, two kinds of fabric vascular prostheses were used. One was a s mall graft used as an endovascular graft and another was a large graft as a n envelope for the small graft, used as the aneurysm wall. Adipose tissue f ragments with fresh blood coagula were injected between the two grafts. The control was a preparation without tissue fragments. Two months and a half after surgery, the test group showed complete connective tissue formation i n the space between the two grafts, but in the control, brownish thrombus r emained. From this experiment, we speculated that tissue fragment transplan tation will accelerate connective tissue formation of the thrombus, and thi s complete organization of the thrombus might reduce endoleakage.