Wondonins A and B, two alkaloids of an unprecedented structural class, alon
g with the previously described dihydroxystyryl sulfates, have been isolate
d from an association of the sponges Poecillastra wondoensis and Jaspis sp.
collected from Keomun Island, Korea. The structures of these compounds hav
e been determined as imidazole alkaloids containing a bis(dihydroxystyrene)
moiety by combined spectroscopic methods. The new compounds exhibited anti
angiogenic activity against human umbilical vein endothelial cells. (C) 200
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