Lipiodol solution of a lipophilic agent, Re-188-TDD, for the treatment of liver cancer

Citation
Jm. Jeong et al., Lipiodol solution of a lipophilic agent, Re-188-TDD, for the treatment of liver cancer, NUCL MED BI, 28(2), 2001, pp. 197-204
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
0969-8051 → ACNP
Volume
28
Issue
2
Year of publication
2001
Pages
197 - 204
Database
ISI
SICI code
0969-8051(200102)28:2<197:LSOALA>2.0.ZU;2-Q
Abstract
Radiolabeled lipiodol has been used for targeting liver cancer. We develope d a lipiodol solution of Re-188-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-dec anedithiol) and investigated its feasibility for the treatment of liver can cer. The lipiodol solution of Re-188-TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of mice, high lung-u ptake was investigated which is evidence of embolizing activity. We also fo und high accumulation in hepatoma after injection through the hepatic arter ies of hepatoma-bearing bearing rats. In conclusion, the lipiodol solution of Re-188-TDD is a promising agent for liver cancer therapy. (C) 2001 Elsev ier Science Inc. All rights reserved.