Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation

M. Ihira et al., Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation, MICROB IMMU, 45(3), 2001, pp. 225-232
Citations number
Categorie Soggetti
Journal title
ISSN journal
0385-5600 → ACNP
Year of publication
225 - 232
SICI code
Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are closely rel ated to each other. Interaction between the two viruses at the time of prim ary HHV-7 infection is suggested by in vivo and in vitro studies. However i nteraction between the two viruses in organ transplant recipients has not b een analyzed. We analyzed serially collected plasma samples obtained from 4 0 living related liver transplant recipients by serological assay (indirect immunofluorescence assay, IFA) and polymerase chain reaction (PCR), Signif icant increase or seroconversion of HHV-6 Ige and HHV-7 IgG antibody titers were observed in 45% and 58% of recipients respectively. Positive rate of IgM HHV-6 antibody increased up to 35% at 4 weeks after transplantation. Ho wever, no remarkable peak in the positive rate of HHV-7 IgM antibody was de monstrated. HHV-6 and HHV-7 DNA were detected in plasma in 15 (38%) and 16 (40%) of the 40 recipients respectively. HHV-6 DNA was detected in 10 (26%) of the 38 recipients at 2 weeks after transplantation. The positive rate o f the virus genome in plasma gradually decreased after that time. HHV-7 DNA was detected in 5 (14%) of the 37 recipients at 2 weeks after transplantat ion; no obvious peak in the positive rate of HHV-7 DNA was demonstrated. An tibody responses involving both HHV-6 and HHV-7, including either a signifi cant increase in IgG antibody titers or positive identification of IgM anti body were observed in 17 (43%) of the 40 recipients, Thirteen out of the 17 recipients demonstrated concurrent antibody response against both viruses. HHV-7 antibody response preceded the HHV-6 antibody response in 2 of the r emaining 4 recipients, whereas the opposite was true in the other 2 recipie nts. Both HHV-6 and HHV-7 DNA were detected in 7 (18%) of the 40 recipients . In 4 of those 7 recipients, DNA from both viruses was concurrently detect ed, 3 of whom had HHV-7 DNA repeatedly detected after first detection of th e virus DNA, The detection of HHV-7 DNA preceded the detection of HHV-6 DNA in 2 recipients, whereas HHV-6 DNA appeared first in 1 recipient.