Evaluation of United States-licensed human immunodeficiency virus immunoassays for detection of group M viral variants

Citation
Wh. Koch et al., Evaluation of United States-licensed human immunodeficiency virus immunoassays for detection of group M viral variants, J CLIN MICR, 39(3), 2001, pp. 1017-1020
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
0095-1137 → ACNP
Volume
39
Issue
3
Year of publication
2001
Pages
1017 - 1020
Database
ISI
SICI code
0095-1137(200103)39:3<1017:EOUSHI>2.0.ZU;2-3
Abstract
Six Food and Drug Administration (FDA)-licensed human immunodeficiency viru s type 1 (HIV-1) and HIV-1/2 immunoassays, including five enzyme immunoassa ys and one rapid test, were challenged with up to 250 serum samples collect ed from various global sites. The serum samples were from individuals known to be infected with variants of HIV-1 including group M subtypes A, B, B', C, D, E, F, and G and group O. All immunoassays detected the vast majority of samples tested. Three samples produced low signal over cutoff values in one or more tests: a clade B sample, an untypeable sample with a low antib ody titer, and a group O sample. It is concluded that HIV-1 immunoassays us ed in the United States are capable of detecting most HIV-1 group M variant s.