Detection of genetic changes in anal intraepithelial neoplasia (AIN) of HIV-positive and HIV-negative men

Citation
T. Haga et al., Detection of genetic changes in anal intraepithelial neoplasia (AIN) of HIV-positive and HIV-negative men, J ACQ IMM D, 26(3), 2001, pp. 256-262
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
ISSN journal
1525-4135 → ACNP
Volume
26
Issue
3
Year of publication
2001
Pages
256 - 262
Database
ISI
SICI code
1525-4135(20010301)26:3<256:DOGCIA>2.0.ZU;2-O
Abstract
Compared with HIV-negative individuals, HIV-positive individuals have a hig her prevalence of anogenital human papillomavirus (HPV) infection, as well as a higher incidence of HPV-associated anal cancer. Little is currently kn own of chromosomal changes occurring in anal intraepithelial neoplasia (AIN ). the probable precursor to anal cancer. Genetic changes in AIN were chara cterized by comparative genomic hybridization (CGH) in a study of samples: obtained from 19 HIV-positive and 11 HIV-negative men. The proportion with genetic changes significantly increased with the severity of the histopatho logic grade with none diagnosed as (0%) AIN 1; 5 of 17 (29%) as AIN 2; and 5 of 9 (56%) AIN 3 showing genetic changes (p = .07). This correlation was also found in study subjects who had multiple biopsies with different grade s of pathology concurrently or serially over time. The most common regional DNA copy number change was gain mapped to chromosome arm 3q (12% of AIN 2 and 33% of AIN 3). This alteration was previously reported to be commonest alteration in cervical cancer, which suggests a common molecular pathway fo r these two HPV-associated anogenital neoplasias.