Borna disease virus and psychiatry

Citation
O. Taieb et al., Borna disease virus and psychiatry, EUR PSYCHIA, 16(1), 2001, pp. 3-10
Citations number
59
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
EUROPEAN PSYCHIATRY
ISSN journal
0924-9338 → ACNP
Volume
16
Issue
1
Year of publication
2001
Pages
3 - 10
Database
ISI
SICI code
0924-9338(200102)16:1<3:BDVAP>2.0.ZU;2-T
Abstract
Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative -stranded RNA virus with a wide geographic distribution, infects several ve rtebrate animal species and causes an immune-mediated central nervous syste m (CNS) disease with various manifestations, depending on both host and vir al factors. In animal infections, BDV can persist in the CNS and induce alt erations in brain cell functions, neurodevelopmental abnormalities and beha vioral disturbances. An association between BDV and psychiatric disorders ( essentially schizophrenia and affective disorders) has been suggested by so me serologic and molecular studies but further investigations are required to substantiate the possible contribution of this virus to the pathogenesis of these disorders. (C) 2001 Editions scientifiques et medicales Elsevier SAS.