GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine

Citation
Mr. Gerasimov et al., GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine, EUR J PHARM, 414(2-3), 2001, pp. 205-209
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
0014-2999 → ACNP
Volume
414
Issue
2-3
Year of publication
2001
Pages
205 - 209
Database
ISI
SICI code
0014-2999(20010302)414:2-3<205:GBOCCI>2.0.ZU;2-A
Abstract
Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better unde rstand the neurochemical mechanisms potentially mediating these cues, we me asured nucleus accumbens dopamine levels in animals exposed to environmenta l cues previously paired with cocaine administration. In animals exposed to a cocaine-paired environment nucleus accumbens dopamine increased by 25%. When administered 2.5 h prior to presentation of the environmental trigger, racemic vigabatrin tan irreversible inhibitor of gamma -aminobutyric acid (GABA)-transaminase) abolished this cue-induced increase. Conversely, R-(-) -vigabatrin, the inactive enantiomer, had no effect. Combined with our earl ier findings, these studies support the potential therapeutic benefit of th is enzyme-based GABAergic strategy to modulate brain dopamine and the subse quent treatment of drug addiction. (C) 2001 Elsevier Science B.V. All right s: reserved.