Transmural heterogeneity of myocardial integrated backscatter in diabetic patients without overt cardiac disease

Citation
J. Naito et al., Transmural heterogeneity of myocardial integrated backscatter in diabetic patients without overt cardiac disease, DIABET RE C, 52(1), 2001, pp. 11-20
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN journal
0168-8227 → ACNP
Volume
52
Issue
1
Year of publication
2001
Pages
11 - 20
Database
ISI
SICI code
0168-8227(200104)52:1<11:THOMIB>2.0.ZU;2-8
Abstract
It is important to detect early changes in diabetic myocardium, because som e diabetic patients suffer from diabetic cardiomyopathy, especially those w ith poorer glycemic control or hypertension (HT). To clarify whether ultras onic tissue characterization can noninvasively detect ultrastructural chang es in diabetic myocardium, we analyzed the transmural heterogeneity in myoc ardial integrated backscatter (THIB) in 20 diabetic patients and 16 normal subjects. THIB was defined as the absolute value of difference of integrate d backscatter between the endocardial and epicardial half of the myocardium . THIB in diabetic patients was significantly greater than that in normal s ubjects. In diabetic patients, there was a significant correlation between glycosylated hemoglobin and THIB. and the greater THIB was shown in patient s with HT compared with those without HT. Early changes in the myocardium, related to increased interstitial collagen deposition or other occult cardi omyopathic changes. may be detected on the basis of quantitative analysis o f THIB in diabetic patients. (C) 2001 Elsevier Science Ireland Ltd. All rig hts reserved.