Recognition memory in normal aging and Parkinson's disease: behavioral andelectrophysiologic measures

Citation
H. Minamoto et al., Recognition memory in normal aging and Parkinson's disease: behavioral andelectrophysiologic measures, COGN BRAIN, 11(1), 2001, pp. 23-32
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
COGNITIVE BRAIN RESEARCH
ISSN journal
0926-6410 → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
23 - 32
Database
ISI
SICI code
0926-6410(200103)11:1<23:RMINAA>2.0.ZU;2-#
Abstract
To assess effects of normal aging and Parkinson's disease (PD) on recogniti on memory, we examined the N400 component of event-related potentials (ERPs ) and behavioral measures during a recognition memory task in 17 normal you ng subjects, 17 normal elderly subjects, and 17 patients with PD. To elicit ERPs, some words were repeated immediately after initial presentation (at lag 0), while others were repeated after one intervening word (at lag 1) or at lag 6. Subjects were requested to push a button with the right thumb up on first presentation of a word and with the left thumb upon repeat present ation. Compared to the normal young subjects, normal elderly subjects showe d reduced accuracy in recognizing repeated words at lags 1 and 6. Compared to the normal elderly group, PD patients showed decreased accuracy in recog nizing lag 6 repetition. N400 amplitude did not differ between the two norm al groups, while PD patients showed lower N400 amplitudes than normal elder ly subjects. The N400 in the young group showed attenuation for lags 0, 1 a nd 6 repetitions, while attenuations in the elderly group and the PD group were noted only for lags 0 and 1 repetitions. These data suggest intact imm ediate but impaired delayed recognition memory in aging and in PD. In addit ion, recognition memory deficits in PD may result, at least partly from the impairment of context integration process. (C) 2001 Elsevier Science B.V. All rights reserved.