Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study

Citation
T. Tsukiura et al., Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study, COGN BRAIN, 11(1), 2001, pp. 13-21
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
COGNITIVE BRAIN RESEARCH
ISSN journal
0926-6410 → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
13 - 21
Database
ISI
SICI code
0926-6410(200103)11:1<13:NDBMAM>2.0.ZU;2-7
Abstract
We used functional magnetic resonance imaging (fMRI) to investigate neural correlates of processes concerning store and manipulation in verbal working memory. We prepared a revised lag I digit span, digit span and a simple nu mber detection task. Specific activities in association with manipulating p rocess were identified in the right middle (BA 9/46) and left precentral gy rus (BA 6). Activated areas specific to maintaining process were detected i n the right middle (right BA 11/10) and medial (BA 6) frontal gyri, the rig ht inferior parietal lobule (BA 30), and the left middle (BA 9) and inferio r frontal gyri (BA 44). The process-nonspecific activated areas common to t wo processes were identified in the right inferior frontal gyrus (BA 47) an d the left superior parietal lobule (BA 7). Using: the signal percent chang e of each subject, we calculated the correlation coefficients among each ac tivated area. The results of this analysis showed that two processes of ver bal working memory were clearly discriminated. The two essential processes bf manipulation and maintenance in workings memory seem to activate process -specific and overlapping (process-nonspecific) areas, but the patterns of combination were definitely different. (C) 2001 Elsevier Science B.V. All r ights reserved.