Performance of antigens used in detecting delayed-type hypersensitivity inadolescents infected with the human immunodeficiency virus

Citation
As. Rogers et al., Performance of antigens used in detecting delayed-type hypersensitivity inadolescents infected with the human immunodeficiency virus, CL DIAG LAB, 8(2), 2001, pp. 273-278
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071-412X → ACNP
Volume
8
Issue
2
Year of publication
2001
Pages
273 - 278
Database
ISI
SICI code
1071-412X(200103)8:2<273:POAUID>2.0.ZU;2-4
Abstract
We examined the performance of delayed-type hypersensitivity (DTH) antigens employing a new Candida albicans product in a human immunodeficiency virus (HIV)-infected and nonanergic adolescent population. Diameters of indurati on (in millimeters) for three intradermally applied antigens (C. albicans, tetanus toxoid, and mumps) were compared in a population of HIV-infected 12 to 18 year olds at study entry in a national multicenter study of HIV dise ase progression. CD4(+) T-cell counts mere measured in quality-controlled l aboratories. The influence of past immunization, gender, and clinical statu s on antigen reactivity was evaluated with contingency table comparisons an d relative risk estimation. Nearly one-half of the 123 eligible subjects we re untreated, and almost three quarters were early in HIV disease by clinic al indicators. There was no statistically significant difference in reactiv ity by past immunization status. Candida antigen (CASTA; Greer Laboratories ) evoked DTH response in a significantly higher number of males and females at every level of induration (largest P value, 0.049 for male comparisons; all P values, <0.001 for females) and in subjects with early and intermedi ate HIV disease at every level of induration (all P values, <0.0001) than e ither tetanus or mumps antigens. No two-antigen combination was as useful a s all three antigens across either gender or clinical categories, although candida and tetanus was the mast useful two-antigen combination at indurati ons of <3 mm. The superior performance of a new C. albicans antigen may ext end the utility of DTH assessment in monitoring immune function.