Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors

Citation
G. Nam et al., Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors, BIOORG MED, 11(5), 2001, pp. 611-614
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
611 - 614
Database
ISI
SICI code
0960-894X(20010312)11:5<611:SAEOPA>2.0.ZU;2-B
Abstract
The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrim idine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the py ridine ring are described. Some of these compounds, especially 51 and 6f, w ere found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting im proved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA). (C) 2001 Elsevier Science Ltd. All rights reserved.