The optimal imaging time for [Tc-99(m)]TRODAT-1/SPET in normal subjects and patients with Parkinson's disease

Citation
Pf. Kao et al., The optimal imaging time for [Tc-99(m)]TRODAT-1/SPET in normal subjects and patients with Parkinson's disease, NUCL MED C, 22(2), 2001, pp. 151-154
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
NUCLEAR MEDICINE COMMUNICATIONS
ISSN journal
0143-3636 → ACNP
Volume
22
Issue
2
Year of publication
2001
Pages
151 - 154
Database
ISI
SICI code
0143-3636(200102)22:2<151:TOITF[>2.0.ZU;2-J
Abstract
Imaging of dopamine transporters (DATs) in the brain using [Tc-99(m)]TRODAT -1 showed excellent pharmacokinetics for estimation of transporter concentr ations. It has been reported that there may be differences in the binding k inetics of DAT radiotracers to DATs between normal subjects and patients wi th Parkinson's disease (PD). The aim of this study was to determine an opti mal time point for [Tc-99(m)]TRODAT-1 brain single photon emission tomograp hy (SPET) acquisition that provides stable target to non-target ratios refl ecting the DAT concentration in the brain. Serial [Tc-99(m)]TRODAT-1 brain SPET images 2, 3 and 4 h after intravenous injection of [Tc-99(m)]TRODAT-1 (925 MBq) were performed in five healthy subjects and nine PD patients. Reg ions of interests were drawn, and caudate/occipital (C/O) and putamen/occip ital (P/O) specific to non-specific [Tc-99(m)]TRODAT-1 binding ratios were calculated. The C/O and P/O ratios in healthy subjects showed consistent in creases with time, but in PD patients, the C/O and P/O ratios of [Tc-99(m)] TRODAT-1 reached a stable level at 3 h post-injection. There was a statisti cally significant difference (P < 0.001) between PD and normal subjects at 4 h post-injection for both the C/O and the P/O ratios. In conclusion, we r ecommend the acquisition of [Tc-99(m)]TRODAT-1 SPET images at 4 h post-inje ction, as at this time point the C/O and P/O ratios can be used to discrimi nate between PD patients and healthy subjects. ( (C) 2001 Lippincott Willia ms & Wilkins).