Reliability of clinical research on invasive fungal infections: a systematic review of the literature

Citation
S. Ascioglu et al., Reliability of clinical research on invasive fungal infections: a systematic review of the literature, MED MYCOL, 39(1), 2001, pp. 35-40
Citations number
22
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
MEDICAL MYCOLOGY
ISSN journal
1369-3786 → ACNP
Volume
39
Issue
1
Year of publication
2001
Pages
35 - 40
Database
ISI
SICI code
1369-3786(200102)39:1<35:ROCROI>2.0.ZU;2-O
Abstract
The aim of this study was to assess the comparability and reliability of cl inical research on invasive fungal infections (IFIs) which is accumulating in the medical literature. A Medline search strategy was developed covering the years 1985-1997, The 7086 articles identified this way were further li mited to 173 by reading the abstracts to studies involving immunocompromise d patients and deep tissue infections. Diagnostic criteria used for definit ions of IFIs were evaluated according to the level of confidence in diagnos is. For analysing the reliability, we used the sample of 397 patients from the European Organization for Research and Treatment of Cancer (EORTC) data base. Each patient in the database was evaluated according to the definitio ns employed in each article. The level of overall agreement among the artic les was very low (Kappa = 0.253). The results of this analysis show the dis crepancy in the medical literature in diagnosing IFIs and the necessity for the standardization of definitions.