A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of gamma -cy
clodextrin, cholic acid, and a dansyl fluorophore in the side chain has bee
n prepared. In this novel CD-peptide, the cholic acid unit acts as an inter
nal guest and forms an intramolecular inclusion complex with gamma -cyclode
xtrin in the CD-peptide. This intramolecular complex works as a host-guest
bridge in the CD-peptide and remarkably stabilizes the alpha -helix structu
re of the CD-peptide.