Remarkable stabilization of the alpha-helix structure by an intramolecularhost-guest bridge in a cyclodextrin-peptide hybrid

Citation
K. Hamasaki et al., Remarkable stabilization of the alpha-helix structure by an intramolecularhost-guest bridge in a cyclodextrin-peptide hybrid, MACRO RAPID, 22(4), 2001, pp. 262-265
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR RAPID COMMUNICATIONS
ISSN journal
1022-1336 → ACNP
Volume
22
Issue
4
Year of publication
2001
Pages
262 - 265
Database
ISI
SICI code
1022-1336(20010228)22:4<262:RSOTAS>2.0.ZU;2-I
Abstract
A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of gamma -cy clodextrin, cholic acid, and a dansyl fluorophore in the side chain has bee n prepared. In this novel CD-peptide, the cholic acid unit acts as an inter nal guest and forms an intramolecular inclusion complex with gamma -cyclode xtrin in the CD-peptide. This intramolecular complex works as a host-guest bridge in the CD-peptide and remarkably stabilizes the alpha -helix structu re of the CD-peptide.