Liver transplantation for biliary atresia associated with malignant hepatic tumors

Citation
Y. Tatekawa et al., Liver transplantation for biliary atresia associated with malignant hepatic tumors, J PED SURG, 36(3), 2001, pp. 436-439
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics
Journal title
JOURNAL OF PEDIATRIC SURGERY
ISSN journal
0022-3468 → ACNP
Volume
36
Issue
3
Year of publication
2001
Pages
436 - 439
Database
ISI
SICI code
0022-3468(200103)36:3<436:LTFBAA>2.0.ZU;2-U
Abstract
The authors report 3 cases of liver transplantations in children between 4 and 10 years of age, complicated with malignant hepatic tumors after biliar y atresia. The preoperative abdominal computed tomography (CT) scans of all 3 cases showed hepatic masses, The serum alpha-fetoprotein levels were ele vated highly in 2 cases. After living-related liver transplantation (LRLT), the pathologic findings of the masses in the resected livers showed hepato cellular carcinoma in 2 cases and hepatoblastoma in the other, All cases we re associated with biliary cirrhosis. The stage of the liver tumor in the 3 cases using the TNM system was IVA (T4, N0, M0), II (T2, N0, M0) and IVA ( T4, N0, M0). Chemotherapy was used in all cases after liver transplantation , and all patients survived with no recurrence. The results suggest that ev en though malignant liver tumors rarely are complicated with biliary atresi a in childhood, one should be alert to the occurrence of hepatic malignancy and perform routine screening of alpha-fetoprotein levels, abdominal CT sc ans, and magnetic resonance imagings, J Pediatr Surg 36:436-439. Copyright (C) 2007 by W.B. Saunders Company.