Uncrossed and crossed projections from the upper cervical spinal cord to the cerebellar nuclei in the rat, studied by anterograde axonal tracing

Citation
M. Matsushita et Gx. Xiong, Uncrossed and crossed projections from the upper cervical spinal cord to the cerebellar nuclei in the rat, studied by anterograde axonal tracing, J COMP NEUR, 432(1), 2001, pp. 101-118
Citations number
68
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF COMPARATIVE NEUROLOGY
ISSN journal
0021-9967 → ACNP
Volume
432
Issue
1
Year of publication
2001
Pages
101 - 118
Database
ISI
SICI code
0021-9967(20010326)432:1<101:UACPFT>2.0.ZU;2-4
Abstract
In the upper cervical spinal segments, neurons in the medial part of lamina VI give rise to uncrossed spinocerebellar axons, whereas the central cervi cal nucleus (CCN) and neurons in laminae VII and VIII give rise to crossed spinocerebellar axons. Using anterograde labeling with biotinylated dextran in the rat, we examined the projections of these neuronal groups to the ce rebellar nuclei. Uncrossed and crossed projections were distinguished by ce rebellar lesions placed on the side contralateral or ipsilateral to the tra cer injections confined to the second and third cervical spinal segments (C 2 and C3, respectively). Labeled terminals of uncrossed projections were se en in the middle, dorsal, and ventrolateral parts of the middle subdivision and in the ventral part of the caudomedial subdivision of the medial nucle us. In the anterior interpositus nucleus, terminals were seen in the middle of the mediolateral extent, whereas, in the posterior interpositus nucleus , they were seen in lateral and caudal parts. The terminals of crossed proj ections from the CCN were distributed ventrally in medial to ventrolateral parts of the middle subdivision of the medial nucleus. Some terminals were seen in the caudomedial subdivision of the medial nucleus. In the anterior interpositus nucleus, labeled terminals were seen mainly in rostromedial pa rts, whereas, in the posterior interpositus nucleus, they were seen in caud al and dorsal parts of the medial half. The present study suggests that the medial lamina VI group and the CCN in the upper cervical segments project to the different areas of the cerebellar nuclei and are concerned with diff erent functions. (C) 2001 Wiley-Liss, Inc.