The cell adhesion molecule Echinoid defines a new pathway that antagonizesthe Drosophila EGF receptor signaling pathway

Citation
Jm. Bai et al., The cell adhesion molecule Echinoid defines a new pathway that antagonizesthe Drosophila EGF receptor signaling pathway, DEVELOPMENT, 128(4), 2001, pp. 591-601
Citations number
61
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
DEVELOPMENT
ISSN journal
0950-1991 → ACNP
Volume
128
Issue
4
Year of publication
2001
Pages
591 - 601
Database
ISI
SICI code
0950-1991(200102)128:4<591:TCAMED>2.0.ZU;2-7
Abstract
Photoreceptor and cone cells in the Drosophila eye are recruited following activation of the epidermal growth factor receptor (EGFR) pathway. We have identified echinoid (ed) as a novel putative cell adhesion molecule that ne gatively regulates EGFR signaling, The ed mutant phenotype is associated wi th extra photoreceptor and cone cells. Conversely, ectopic expression of ed in the eye leads to a reduction in the number of photoreceptor cells. ed e xpression is independent of EGFR signaling and ED is localized to the plasm a membrane of every cells throughout the eye disc. We present evidence that ed acts nonautonomously to generate extra R7 cells by a mechanism that is sina-independent but upstream of Tramtrack (TTK88). Together, our results s upport a model whereby ED defines an independent pathway that antagonizes E GFR signaling by regulating the activity, but not the level, of the TTK88 t ranscriptional repressor.