Exogenous melatonin affects lipids and enzyme activities in mink (Mustela vison) liver

Citation
P. Nieminen et al., Exogenous melatonin affects lipids and enzyme activities in mink (Mustela vison) liver, COMP BIOC C, 128(2), 2001, pp. 203-211
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN journal
1532-0456 → ACNP
Volume
128
Issue
2
Year of publication
2001
Pages
203 - 211
Database
ISI
SICI code
1532-0456(200102)128:2<203:EMALAE>2.0.ZU;2-#
Abstract
Exogenous melatonin as subcutaneous 2.7-mg implants was given to eight fema le and male minks in late July with an equal number of animals in the contr ol groups. The liver enzyme activities and major lipids of liver and plasma were measured in October-November. Melatonin had Very pronounced effects o n the lipid and carbohydrate metabolism of the minks and there was also a c lear sexual dimorphism. In the males, melatonin decreased the lipase estera se activity of the liver. In the liver of the females, however, melatonin i ncreased the glucose-6-phosphatase activity. Due to melatonin treatment the liver triacylglycerol contents diminished in both sexes. At the same time, in the females the liver cholesterol levels were decreased. In the plasma lipids, the only change was a fall in the polar lipids of the melatonin-tre ated females. Melatonin seems to be responsible for the metabolic changes a ssociated with the onset of wintering, especially for the acceleration of t he deposition of subcutaneous fat reserves. The smaller females experience the effects of exogenous melatonin more rapidly than the males. Perhaps the smaller body size requires an earlier onset of metabolic preparation for t he winter. (C) 2001 Elsevier Science Inc. All rights reserved.