Hematological studies on black cumin oil from the seeds of Nigella sativa L.

Citation
S. Enomoto et al., Hematological studies on black cumin oil from the seeds of Nigella sativa L., BIOL PHAR B, 24(3), 2001, pp. 307-310
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
307 - 310
Database
ISI
SICI code
0918-6158(200103)24:3<307:HSOBCO>2.0.ZU;2-P
Abstract
The methanol soluble portion of black cumin oil, which is prepared by compr ession of seeds of Nigella saliva L., showed inhibitory effects on arachido nic acid (AA)-induced platelet aggregation and blood coagulation. By bioact ive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzen ediol (1) and two known compounds, thymol (2), carvacrol (3), having ver?; strong inhibitory activity. Further, we then examined the isolated compound s (1-3) and eight related compounds by the screening test for AA-induced pl atelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl gro up had more potent activity than aspirin, which is well known as a remedy f or thrombosis.