Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer

Citation
Sg. Wang et al., Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer, POLYM ADV T, 12(3-4), 2001, pp. 253-258
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
POLYMERS FOR ADVANCED TECHNOLOGIES
ISSN journal
1042-7147 → ACNP
Volume
12
Issue
3-4
Year of publication
2001
Pages
253 - 258
Database
ISI
SICI code
1042-7147(200103/04)12:3-4<253:DA5RBI>2.0.ZU;2-U
Abstract
The in vitro degradation behavior of the polyester/polyether copolymer base d on polycaprolactone/poly(ethylene oxide)/polylactide (PCEL) significantly depends on the caproxyl (CL)/lactyl (LA) ratio for the same poly(ethylene oxide) (PEO) content. The PCEL copolymer with rich CL units shows the cryst alline structure of PCL with a slow degradation rate while it presents crys talline structure of poly-L-lactide (PLLA) with more LA units that has a fa st degradation rate. In the case of PCEL with similar CL and LA unit conten ts, it only exhibits the crystalline structure of PEO and the degradation r ate is faster especially during the early stage of the degradation due to t he rapid cleavage of the PEG. The drug release system is prepared using 5-f luorouracil (5-Fu) as the model drug and PCEL copolymers as the drug carrie rs. It is shown that the drug release rate is controlled by the composition , morphology and properties of the PCEL copolymer. In particular, the PCEL copolymer with 70% LA units displays a near zero-order sustained release in about 60 days. Therefore these copolymers have potential application as a controlled 5-fluorouracil delivery system. Copyright (C) 2001 John Wiley & Sons, Ltd.